Details:

12A12

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:12A12 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Patient 12Best neutralization breadth IC50, %:96*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):0.07*
# of studies in bNAber:2Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Scheid2011100*100*92*100*NA86*83*75*92*
Georgiev2013100*94*96*100*NANA100*100*96*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Scheid20110.07*0.58*0.3*0.63*NA0.2*0.1*0.13*0.25*
Georgiev20130.04*0.12*0.04*5.01*NANA0.03*0.02*0.07*
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-2
PutativeJgeneIGHJ4/5
CDR3 length aa15
CDR3sequence aaARDGSGDDTSWHLDP
Somatic mutations aa34
Somatic mutations na67
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1D-33
PutativeJgeneIGKJ3
CDR3 length aa5
CDR3sequence aaCAVLEFF
Somatic mutations na23 (26)
Somatic mutations aa49 (53)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: CCD30922 Light Chain DNA: HE584540
Heavy Chain AA: CCD30921 Heavy Chain DNA: HE584539

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database