Details:

12A21

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:12A21 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4JPW

3D Structure Viewer: 4JPW
Donor:Patient 12Best neutralization breadth IC50, %:*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):*
# of studies in bNAber:0Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-2
PutativeJgeneIGHJ4/5
CDR3 length aa15
CDR3sequence aaARDESGDDLKWHLHP
Somatic mutations aa31
Somatic mutations na64
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1D-33
PutativeJgeneIGKJ3
CDR3 length aa5
CDR3sequence aaCAVFQWF
Somatic mutations na22 (25)
Somatic mutations aa43 (48)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
4JPW
GenBankLight Chain AA: HE584542 Light Chain DNA: HE584542
Heavy Chain AA: HE584541 Heavy Chain DNA: HE584541

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database