Details:

2F5

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:2F5 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3MOA

3D Structure Viewer: 3MOA 3MOB 3MOD 3LEV 3IDG 3IDI 3IDJ 3IDM 3IDN 3EGS 3DRT 3BQU 3D0L 3DRQ 3D0V 3DRO 2PW1 2PW2 2P8L 2P8M 2P8P 2PR4 1TJG 1TJH 1TJI 1U8H 1U8I 1U8J 1U8O 1U8P 1U8Q 1U91 1U92 2F5A 1U95 1U8M
Donor:unknownBest neutralization breadth IC50, %:61*
Binding Site:gp41 MPERNeutralization breadth IC80, %:NA
Primary Reference:7520721Best neutralization potency (in μg/ml):1.44*
# of studies in bNAber:4Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201386*82*13*67*NANA94*56*59*
Huang201283*82*11*67*NANA94*69*57*
Walker200978*68*7*56*87*80*90*80*61*
Georgiev201385*77*7*50*NANA100*NA56*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20132.37*1.43*3.29*1.53*NANA0.46*4.27*2.12*
Huang20122.37*1.64*13.2*1.53*NANA0.46*4.3*2.29*
Walker20095.7*2.41*31.52*3.18*1.78*1.25*0.24*0.65*2.27*
Georgiev20132.24*1.35*19.5*0.03*NANA0.13*NA1.44*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV2-5
PutativeJgeneJ6*02
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
3MOA3MOB3MOD3LEV3IDG3IDI3IDJ3IDM3IDN3EGS3DRT3BQU
3D0L3DRQ3D0V3DRO2PW12PW22P8L2P8M2P8P2PR41TJG
1TJH1TJI1U8H1U8I1U8J1U8O1U8P1U8Q1U911U922F5A
1U951U8M
GenBankLight Chain AA: 1TJG_L
Heavy Chain AA: 1TJG_H

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database