Details:

2G12

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:2G12 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 1ZLS

3D Structure Viewer: 1ZLS 1ZLU 1ZLV 1ZLW 2OQJ 3OAU 3OAY 3OAZ 3OB0
Donor:unknownBest neutralization breadth IC50, %:39*
Binding Site:othersNeutralization breadth IC80, %:NA
Primary Reference:7520721Best neutralization potency (in μg/ml):1.45*
# of studies in bNAber:2Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker200937*71*11*24*27*20*NA50*33*
Georgiev201330*71*11*100*NANANA100*39*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker200917.11*0.82*2.93*7.71*5.52*31.03*NA0.95*1.94*
Georgiev20131.54*1.23*13.4*0.94*NANANA0.72*1.45*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-21
PutativeJgeneJ3*01
CDR3 length aa13
CDR3sequence aaARKGEAAAGTIDY
Somatic mutations aa0
Somatic mutations na0 (2)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa13
CDR3sequence aaCARKGEAAAGTIDYW
Somatic mutations na0
Somatic mutations aa0 (2)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
1ZLS1ZLU1ZLV1ZLW2OQJ3OAU3OAY3OAZ3OB0
GenBankLight Chain AA: 1ZLV_L Light Chain DNA: GQ232867
Heavy Chain AA: 1ZLV_H

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database