Details:

3BNC55

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:3BNC55 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Patient 3Best neutralization breadth IC50, %:64*
Binding Site:othersNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):0.57*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Scheid2011100*76*65*75*NA71*67*50*64*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Scheid20110.21*2.2*0.64*5.05*NA0.48*0.83*0.26*0.57*
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-2
PutativeJgeneIGHJ2/6
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1D-33
PutativeJgeneIGKJ1/3
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBank
NA

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database