Details:

3BNC60

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:3BNC60 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3RPI

3D Structure Viewer: 3RPI 4GW4
Donor:Patient 3Best neutralization breadth IC50, %:*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):*
# of studies in bNAber:0Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-2
PutativeJgeneIGHJ2/6
CDR3 length aa12
CDR3sequence aaARQRSDFWDFDV
Somatic mutations aa38
Somatic mutations na83 (84)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1-5
PutativeJgeneIG1/5
CDR3 length aa5
CDR3sequence aaCQVYEFI
Somatic mutations na23 (25)
Somatic mutations aa46 (49)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
3RPI4GW4
GenBankLight Chain AA: HE584536 Light Chain DNA: HE584536
Heavy Chain AA: HE584535 Heavy Chain DNA: HE584535

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database