Details:

4e10

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:4e10 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:unknownBest neutralization breadth IC50, %:100*
Binding Site:gp41 MPERNeutralization breadth IC80, %:NA
Primary Reference:7520721Best neutralization potency (in μg/ml):1.62*
# of studies in bNAber:4Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang2013100*100*98*100*NANA100*89*98*
Huang2012100*100*98*100*NANA100*94*97*
Walker200996*97*96*96*100*100*100*100*97*
Georgiev2013100*100*100*100*NANA100*100*100*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20132.2*1.2*1.79*3.12*NANA0.75*0.54*1.77*
Huang20122.21*1.2*1.95*3.12*NANA0.75*0.76*1.92*
Walker20096.2*5.22*3.23*4.6*1.87*1.44*0.64*1.42*3.19*
Georgiev20131.91*1.6*1.8*1.01*NANA0.15*0.08*1.62*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-69
PutativeJgeneJ4*02
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: 2FX7_L
Heavy Chain AA: 2FX7_H

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database