Details:

8ANC195

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:8ANC195 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Patient 8Best neutralization breadth IC50, %:67*
Binding Site:othersNeutralization breadth IC80, %:NA
Primary Reference:21764753Best neutralization potency (in μg/ml):0.87*
# of studies in bNAber:3Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201350*72*52*89*NANA75*56*61*
Scheid201150*65*65*100*NA86*83*38*67*
Georgiev201350*71*46*100*NANA100*NA60*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20131.3*0.31*3.92*0.6*NANA0.59*0.74*0.94*
Scheid20111.52*0.34*6.77*0.53*NA0.55*0.85*0.32*0.88*
Georgiev20131.3*0.3*5.17*0.8*NANA0.66*NA0.87*
Sequence Information:
Heavy Chain
PutativeVgeneIGVH1-69
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1D-33
PutativeJgeneIGKJ3
CDR3 length aa9
CDR3sequence aaCQQYDTYPGTF
Somatic mutations na26 (27)
Somatic mutations aa41 (45)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: HE584554 Light Chain DNA: HE584554
Heavy Chain AA: HE584553 Heavy Chain DNA: HE584553

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database