Details:

CAP256-VRC26.08

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:CAP256-VRC26.08 - XML ExportAlternate Names:VRC26.08No structure data available!
Donor:CAP256Best neutralization breadth IC50, %:100*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:24590074Best neutralization potency (in μg/ml):5*
# of studies in bNAber:1Polyreactivity:No
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Sok2014100*100*100*100*NA100*100*100*100*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Sok20140.07*20*0.01*10*NA2.51*20*0.01*5*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-30*18
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV1-51*02
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AHX01239.1 Light Chain DNA: KJ134885.1
Heavy Chain AA: AHX01227.1 Heavy Chain DNA: KJ134873.1

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database