Details:

CH01

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:CH01 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Subject CH0219Best neutralization breadth IC50, %:*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21795340Best neutralization potency (in μg/ml):*
# of studies in bNAber:0Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-20
PutativeJgeneIGHJ2
CDR3 length aa26
CDR3sequence aaARGTDYTIDDAGIHYQGSGTFWYFDL
Somatic mutations aa28
Somatic mutations na48 (49)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20
PutativeJgeneIGKJ1
CDR3 length aa9
CDR3sequence aaCQQYGGSPYTF
Somatic mutations na16
Somatic mutations aa32 (35)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AFF19542 Light Chain DNA: JQ267519
Heavy Chain AA: AFF19546 Heavy Chain DNA: JQ267523

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database