Details:

CH04

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:CH04 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3TCL

3D Structure Viewer: 3TCL 3U46 3U4B
Donor:Subject CH0219Best neutralization breadth IC50, %:*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21795340Best neutralization potency (in μg/ml):*
# of studies in bNAber:0Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-20
PutativeJgeneIGHJ2
CDR3 length aa26
CDR3sequence aaARGTDYTIDDQGIRYQGSGTFWYFDV
Somatic mutations aa23
Somatic mutations na41 (42)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20
PutativeJgeneIGKJ1
CDR3 length aa9
CDR3sequence aaCQQYGRSPYTF
Somatic mutations na16
Somatic mutations aa31 (34)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
3TCL3U463U4B
GenBankLight Chain AA: AFF19545 Light Chain DNA: JQ267522
Heavy Chain AA: AFF19549 Heavy Chain DNA: JQ267526

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database