Details:

CH103

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:CH103 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4JAN

3D Structure Viewer: 4JAN 4JAM
Donor:CH505Best neutralization breadth IC50, %:84*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:23552890Best neutralization potency (in μg/ml):0.18*
# of studies in bNAber:2Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201382*90*83*100*NANA94*56*84*
Liao201368*77*52*NANANANANA64*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20130.24*0.12*0.62*0.39*NANA0.14*0.05*0.18*
Liao20138.37*2.3*7.29*NANANANANA6.92*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-59*01
PutativeJgeneIGHJ4*02
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV3-1*01
PutativeJgeneIGLJ1*01
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
4JAN4JAM
GenBankLight Chain AA: 4JAM_L
Heavy Chain AA: 4JAM_H

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database