bNAb: | M66.6 - XML Export | Alternate Names: | No alternate names known | No structure data available! |
Donor: | SC44 | Best neutralization breadth IC50, %: | 31* |
Binding Site: | gp41 MPER | Neutralization breadth IC80, %: | NA |
Primary Reference: | 21880764 | Best neutralization potency (in μg/ml): | 22.25* |
# of studies in bNAber: | 1 | Polyreactivity: | Yes |
Competition of bNAbs with sCD4 and bNAbs in ELISA: |
sCD4 | b12 | a2G12 | F425 | X5 | PG9 | PGT121 | PGT125 | PGT130 | PGT135 | NA | NA | NA | NA | NA | NA | NA | NA | NA | NA |
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Percent viruses neutralized with an IC50 < 50 μg/ml: |
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Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml: |
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Sequence Information: | Heavy Chain | PutativeVgene | | PutativeJgene | | CDR3 length aa | | CDR3sequence aa | | Somatic mutations aa | | Somatic mutations na | | Mutation frequency na | | Mutation frequency aa | | InsertionDeletions aa pos | |
| Light Chain | PutativeVgene | | PutativeJgene | | CDR3 length aa | 9 | CDR3sequence aa | CQQSYSTPFTF | Somatic mutations na | 4 | Somatic mutations aa | 4 (6) | Mutation frequency na | | Mutation frequency aa | | InsertionDeletions aa pos | |
| Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs. |
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External Resources: |
EMDataBank | NA |
PDB | NA |
GenBank | Light Chain AA: JN252503 Light Chain DNA: JN252503 Heavy Chain AA: JN252502 Heavy Chain DNA: JN252502 |