Details:

M66.6

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:M66.6 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:SC44Best neutralization breadth IC50, %:31*
Binding Site:gp41 MPERNeutralization breadth IC80, %:NA
Primary Reference:21880764Best neutralization potency (in μg/ml):22.25*
# of studies in bNAber:1Polyreactivity:Yes
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev201335*45*4*50*NANA100*NA31*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev201323.8*20.35*40.4*6.29*NANA21.6*NA22.25*
Sequence Information:
Heavy Chain
PutativeVgene
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa9
CDR3sequence aaCQQSYSTPFTF
Somatic mutations na4
Somatic mutations aa4 (6)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN252503 Light Chain DNA: JN252503
Heavy Chain AA: JN252502 Heavy Chain DNA: JN252502

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database