Details:

PG16

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PG16 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3LRS

3D Structure Viewer: 3LRS 3MME 3MUG 4DQO
Donor:Protocol G African donor 24Best neutralization breadth IC50, %:79*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:19729618Best neutralization potency (in μg/ml):0.02*
# of studies in bNAber:5Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201393*56*77*22*NANA81*100*74*
Huang201290*56*76*22*NANA81*94*73*
Walker200985*74*78*60*67*73*100*60*74*
Georgiev2013100*61*86*50*NANA67*100*79*
Huang201490*56*76*22*NANA81*94*74*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20130.01*0.1*0.01*2.44*NANA0.02*0.1*0.02*
Huang20120.01*0.1*0.02*2.44*NANA0.02*0.1*0.02*
Walker20090.11*0.7*0.25*0.02*0.05*1.21*0.04*0.03*0.14*
Georgiev20130.01*0.14*0.01*0.16*NANA0.02*0.05*0.02*
Huang20140.01*0.1*0.02*2.44*NANA0.02*0.1*0.02*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-33
PutativeJgeneJ6*03
CDR3 length aa30
CDR3sequence aaAREAGGPIWHDDVKYYDFNDGYYNYHYMDV
Somatic mutations aa21
Somatic mutations na43
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGVL2-14*01
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
3LRS3MME3MUG4DQO
GenBankLight Chain AA: GU272044
Heavy Chain AA: GU272043

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database