Details:

PG9

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PG9 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3U36

3D Structure Viewer: 3U36 3U2S 3MUH 3U4E
Donor:Protocol G African donor 24Best neutralization breadth IC50, %:84*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:19729618Best neutralization potency (in μg/ml):0.08*
# of studies in bNAber:8Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201185*68*74*76*67*80*90*60*74*
Chuang201393*59*83*56*NANA88*100*79*
Huang201290*59*81*56*NANA88*94*78*
Walker200985*74*78*76*67*80*100*80*78*
Georgiev2013100*65*93*100*NANA67*100*83*
Falkowska2014100*75*85*100*NA86*100*88*84*
Huang201490*59*81*56*NANA88*94*78*
Sok2014100*73*84*100*NA83*100*88*84*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.14*0.86*0.39*0.21*0.1*1.13*0.06*0.17*0.26*
Chuang20130.04*0.25*0.09*0.29*NANA0.09*0.1*0.08*
Huang20120.04*0.25*0.08*0.29*NANA0.09*0.1*0.08*
Walker20090.16*0.43*0.23*0.1*0.09*0.3*0.1*0.8*0.22*
Georgiev20130.04*0.28*0.09*2.02*NANA0.08*0.1*0.08*
Falkowska20140.06*2.05*0.05*0.71*NA0.25*0.78*0.08*0.12*
Huang20140.04*0.25*0.08*0.29*NANA0.09*0.1*0.08*
Sok20140.06*1.13*0.05*0.71*NA0.21*0.78*0.08*0.1*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-20
PutativeJgeneJ2*01
CDR3 length aa30
CDR3sequence aaVREAGGPDYRNGYNYYDFYDGYYNYHYMDV
Somatic mutations aa19
Somatic mutations na41
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGVL2-14*01
PutativeJgene
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankEMD-2241
PDB
3U363U2S3MUH3U4E
GenBankLight Chain AA: GU272046
Heavy Chain AA: GU272045

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database