Details:

PGDM1400

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGDM1400 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4RQQ

3D Structure Viewer: 4RQQ
Donor:Donor 84Best neutralization breadth IC50, %:100*
Binding Site:Neutralization breadth IC80, %:NA
Primary Reference:2147483647Best neutralization potency (in μg/ml):0.01*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Sok2014100*100*100*100*NA100*100*100*100*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Sok20140*1.65*0*0.01*NA0.06*0.02*0*0.01*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-8
PutativeJgeneIGHJ6
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV2-28
PutativeJgeneIGKJ1
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
4RQQ
GenBank
NA

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database