Details:

PGT121

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT121 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4FQ1

3D Structure Viewer: 4FQ1 4FQC 4JY4
Donor:Donor 17Best neutralization breadth IC50, %:69*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.03*
# of studies in bNAber:2Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+—++++++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201163*84*85*48*93*80*NA70*69*
Sok201450*100*64*50*NA83*14*75*66*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.03*0.02*0.02*0.01*0.14*0.02*NA0.49*0.03*
Sok20140.05*0.04*0.1*0.01*NA0*2.86*9.67*0.03*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-59
PutativeJgeneJ6*03
CDR3 length aa24
CDR3sequence aaTLHGRRIYGIVAFNEWFTYFYMDV
Somatic mutations aa27
Somatic mutations na65
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV3-21*02
PutativeJgeneIGLJ3*02
CDR3 length aa12
CDR3sequence aaHIWDSRVPTKWV
Somatic mutations na31
Somatic mutations aa56
Mutation frequency na0.1
Mutation frequency aa0.3
InsertionDeletions aa pos-7 in FR1/+3 in FR3
External Resources:
EMDataBankEMD-5624:
PDB
4FQ14FQC4JY4
GenBankLight Chain AA: JN201911 Light Chain DNA: JN201911
Heavy Chain AA: JN201894 Heavy Chain DNA: JN201894

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database