bNAb: | PGT121 - XML Export | Alternate Names: | No alternate names known | Representative Structure: 4FQ1
 3D Structure Viewer: 4FQ1 4FQC 4JY4 |
Donor: | Donor 17 | Best neutralization breadth IC50, %: | 69* |
Binding Site: | V3 glycan | Neutralization breadth IC80, %: | NA |
Primary Reference: | 21849977 | Best neutralization potency (in μg/ml): | 0.03* |
# of studies in bNAber: | 2 | Polyreactivity: | Not Reported |
Competition of bNAbs with sCD4 and bNAbs in ELISA: |
sCD4 | b12 | a2G12 | F425 | X5 | PG9 | PGT121 | PGT125 | PGT130 | PGT135 | + | — | +++ | ++ | + | +++ | +++ | +++ | + | ++
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Percent viruses neutralized with an IC50 < 50 μg/ml: |
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Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml: |
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Sequence Information: | Heavy Chain | PutativeVgene | IGHV4-59 | PutativeJgene | J6*03 | CDR3 length aa | 24 | CDR3sequence aa | TLHGRRIYGIVAFNEWFTYFYMDV | Somatic mutations aa | 27 | Somatic mutations na | 65 | Mutation frequency na | 0.1 | Mutation frequency aa | 0.2 | InsertionDeletions aa pos |
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| Light Chain | PutativeVgene | IGLV3-21*02 | PutativeJgene | IGLJ3*02 | CDR3 length aa | 12 | CDR3sequence aa | HIWDSRVPTKWV | Somatic mutations na | 31 | Somatic mutations aa | 56 | Mutation frequency na | 0.1 | Mutation frequency aa | 0.3 | InsertionDeletions aa pos | -7 in FR1/+3 in FR3
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External Resources: |
EMDataBank | EMD-5624: |
PDB | 4FQ14FQC4JY4GenBank | Light Chain AA: JN201911 Light Chain DNA: JN201911 Heavy Chain AA: JN201894 Heavy Chain DNA: JN201894 | |