Details:

PGT122

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT122 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4JY5

3D Structure Viewer: 4JY5 4NCO
Donor:Donor 17Best neutralization breadth IC50, %:65*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.06*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201159*84*81*40*80*80*NA60*65*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.06*0.02*0.03*0.02*0.44*0.06*NA7.5*0.06*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-59
PutativeJgeneJ6*03
CDR3 length aa24
CDR3sequence aaTKHGRRIYGVVAFKEWFTYFYMDV
Somatic mutations aa31
Somatic mutations na68
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV3-21*02
PutativeJgeneIGLJ3*02
CDR3 length aa12
CDR3sequence aaHIWDSRRPTNWV
Somatic mutations na27
Somatic mutations aa58
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos-7 in FR1/+3 in FR3
External Resources:
EMDataBankNA
PDB
4JY54NCO
GenBankLight Chain AA: JN201912 Light Chain DNA: JN201912
Heavy Chain AA: JN201895 Heavy Chain DNA: JN201895

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database