Details:

pgt123

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:pgt123 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 17Best neutralization breadth IC50, %:66*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.03*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201159*81*85*48*80*80*NA60*66*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.02*0.02*0.01*0.02*0.1*0.04*NA1.33*0.03*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-59
PutativeJgeneJ6*03
CDR3 length aa24
CDR3sequence aaALHGKRIYGIVALGELFTYFYMDV
Somatic mutations aa35
Somatic mutations na79
Mutation frequency na0.2
Mutation frequency aa0.2
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV3-21*02
PutativeJgeneIGLJ3*02
CDR3 length aa12
CDR3sequence aaHIYDARGGTNWV
Somatic mutations na39
Somatic mutations aa73
Mutation frequency na0.2
Mutation frequency aa0.3
InsertionDeletions aa pos-7 in FR1/+3 in FR3
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201913 Light Chain DNA: JN201913
Heavy Chain AA: JN201896 Heavy Chain DNA: JN201896

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database