Details:

pgt125

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:pgt125 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 36Best neutralization breadth IC50, %:52*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.04*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
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Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201167*74*56*40*20*27*60*30*52*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.01*0.02*1.83*0.09*0.04*0.02*0.05*0.01*0.04*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa19
CDR3sequence aaFDGEVLVYNHWPKPAWVDL
Somatic mutations aa36
Somatic mutations na78
Mutation frequency na0.2
Mutation frequency aa0.2
InsertionDeletions aa pos+6 in CDR2
Light Chain
PutativeVgeneIGLV2-8*01
PutativeJgeneIGLJ2*01 or IGLJ3*01
CDR3 length aa10
CDR3sequence aaGSLVGNWDVI
Somatic mutations na23
Somatic mutations aa46
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos-5 in CDR1
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AEN14410 Light Chain DNA: JN201914.1
Heavy Chain AA: AEN14393 Heavy Chain DNA: JN201897

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database