Details:

PGT127

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT127 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3TWC

3D Structure Viewer: 3TWC
Donor:Donor 36Best neutralization breadth IC50, %:50*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.08*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201152*81*52*48*27*40*NA40*50*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.02*0.06*0.55*0.5*1.85*0.27*NA0.04*0.08*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa19
CDR3sequence aaFGGEVLVYRDWPKPAWVDL
Somatic mutations aa30
Somatic mutations na58
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos+6 in CDR2
Light Chain
PutativeVgeneIGLV2-8*01
PutativeJgeneIGLJ2*01 or IGLJ3*01
CDR3 length aa10
CDR3sequence aaSSLVGNWDVI
Somatic mutations na13
Somatic mutations aa27
Mutation frequency na0.0
Mutation frequency aa0.1
InsertionDeletions aa pos-5 in CDR1
External Resources:
EMDataBankNA
PDB
3TWC
GenBankLight Chain AA: JN201916 Light Chain DNA: JN201916
Heavy Chain AA: JN201899 Heavy Chain DNA: JN201899.1

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database