Details:

PGT128

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT128 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3TV3

3D Structure Viewer: 3TV3 3TYG
Donor:Donor 36Best neutralization breadth IC50, %:71*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.02*
# of studies in bNAber:3Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201159*81*78*60*80*67*60*90*71*
Huang201462*77*69*56*NANA44*50*63*
Sok201450*87*44*NANA17*86*38*58*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.01*0.01*0.04*0.02*0.56*0.06*0.06*0.67*0.02*
Huang20140.02*0.01*0.04*0.07*NANA0.1*0.03*0.03*
Sok20140.06*0.02*0.03*NANA0.02*0.02*0.03*0.02*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa19
CDR3sequence aaFGGEVLRYTDWPKPAWVDL
Somatic mutations aa36
Somatic mutations na75
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos+6 in CDR2
Light Chain
PutativeVgeneIGLV2-8*01
PutativeJgeneIGLJ2*01 or IGLJ3*01
CDR3 length aa10
CDR3sequence aaGSLVGNWDVI
Somatic mutations na14
Somatic mutations aa27
Mutation frequency na0.0
Mutation frequency aa0.1
InsertionDeletions aa pos-5 in CDR1
External Resources:
EMDataBankEMD-1970
PDB
3TV33TYG
GenBankLight Chain AA: JN201917 Light Chain DNA: JN201917
Heavy Chain AA: JN201900 Heavy Chain DNA: JN201900

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database