Details:

PGT130

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT130 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 36Best neutralization breadth IC50, %:52*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.16*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201152*65*48*44*33*47*80*50*52*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.08*0.1*0.15*0.65*0.07*4.14*0.21*0.04*0.16*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa19
CDR3sequence aaSGGDILYYYEWQKPHWFSP
Somatic mutations aa42
Somatic mutations na83
Mutation frequency na0.2
Mutation frequency aa0.3
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV2-8*01
PutativeJgeneIGLJ2*01 or IGLJ3*01
CDR3 length aa10
CDR3sequence aaSSLFGRWDVV
Somatic mutations na21
Somatic mutations aa39
Mutation frequency na0.1
Mutation frequency aa0.1
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201918 Light Chain DNA: JN201918
Heavy Chain AA: JN201901 Heavy Chain DNA: JN201901

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database