Details:

PGT131

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT131 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 36Best neutralization breadth IC50, %:40*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.52*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++++++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201141*45*41*36*13*40*60*40*40*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.05*0.07*0.78*0.85*1.43*3.61*0.13*0.54*0.52*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa19
CDR3sequence aaSGGDILYYIEWQKPHWFYP
Somatic mutations aa41
Somatic mutations na84
Mutation frequency na0.2
Mutation frequency aa0.3
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGLV2-8*01
PutativeJgeneIGLJ2*01 or IGLJ3*01
CDR3 length aa10
CDR3sequence aaSSLSGRWDIV
Somatic mutations na25
Somatic mutations aa44
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201919 Light Chain DNA: JN201919
Heavy Chain AA: JN201902 Heavy Chain DNA: JN201902

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database