Details:

PGT135

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT135 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4JM2

3D Structure Viewer: 4JM2 4JM4
Donor:Donor 39Best neutralization breadth IC50, %:33*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.17*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
++++++++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201122*39*37*24*60*40*NA20*33*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.35*0.15*0.05*1.75*0.21*0.14*NA29.89*0.17*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV4-39*07
PutativeJgeneIGHJ5*02
CDR3 length aa18
CDR3sequence aaHRHHDVFMLVPIAGWFDV
Somatic mutations aa37
Somatic mutations na67
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos+5 in CDR1
Light Chain
PutativeVgeneIGKV3-15*01
PutativeJgeneIGLJ1*01
CDR3 length aa9
CDR3sequence aaQQYEEWPRT
Somatic mutations na29
Somatic mutations aa51
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankEMD-2331
PDB
4JM24JM4
GenBankLight Chain AA: JN201920 Light Chain DNA: JN201920
Heavy Chain AA: JN201903 Heavy Chain DNA: JN201903

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database