Details:

PGT136

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT136 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 39Best neutralization breadth IC50, %:16*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:23024643Best neutralization potency (in μg/ml):7.82*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
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Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20114*19*33*4*13*27*NA10*16*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20112.34*14.41*7.52*0.05*5.86*26.2*NA29.11*7.82*
Sequence Information:
Heavy Chain
PutativeVgene
PutativeJgene
CDR3 length aa18
CDR3sequence aaHKYHDIFRVVPVAGWFDP
Somatic mutations aa33
Somatic mutations na60
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos+5 in CDR1/+1 in CDR2
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa9
CDR3sequence aaQQYEEWPRT
Somatic mutations na22
Somatic mutations aa39
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AEN14417 Light Chain DNA: JN201921.1
Heavy Chain AA: AEN14400 Heavy Chain DNA: JN201904.1

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database