Details:

PGT137

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT137 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 39Best neutralization breadth IC50, %:22*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:23024643Best neutralization potency (in μg/ml):3.46*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201126*19*33*12*20*33*NA10*22*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20113.52*8.58*0.23*6.3*6.23*0.23*NA28.3*3.46*
Sequence Information:
Heavy Chain
PutativeVgene
PutativeJgene
CDR3 length aa18
CDR3sequence aaHKYHDIVMVVPIAGWFDP
Somatic mutations aa38
Somatic mutations na77
Mutation frequency na0.2
Mutation frequency aa0.2
InsertionDeletions aa pos+5 in CDR1
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa9
CDR3sequence aaQQYEEWPRT
Somatic mutations na19
Somatic mutations aa35
Mutation frequency na0.1
Mutation frequency aa0.1
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AEN14418 Light Chain DNA: JN201922.1
Heavy Chain AA: AEN14401 Heavy Chain DNA: JN201905.1

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database