Details:

pgt137

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:pgt137 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 39Best neutralization breadth IC50, %:22*
Binding Site:V3 glycanNeutralization breadth IC80, %:NA
Primary Reference:23024643Best neutralization potency (in μg/ml):3.46*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
+++++++
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201126*19*33*12*20*33*NA10*22*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20113.52*8.58*0.23*6.3*6.23*0.23*NA28.3*3.46*
Sequence Information:
Heavy Chain
PutativeVgene
PutativeJgene
CDR3 length aa18
CDR3sequence aaHKYHDIVMVVPIAGWFDP
Somatic mutations aa38
Somatic mutations na77
Mutation frequency na0.2
Mutation frequency aa0.2
InsertionDeletions aa pos+5 in CDR1
Light Chain
PutativeVgene
PutativeJgene
CDR3 length aa9
CDR3sequence aaQQYEEWPRT
Somatic mutations na19
Somatic mutations aa35
Mutation frequency na0.1
Mutation frequency aa0.1
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: AEN14418 Light Chain DNA: JN201922.1
Heavy Chain AA: AEN14401 Heavy Chain DNA: JN201905.1

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database