Details:

PGT142

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT142 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 84Best neutralization breadth IC50, %:56*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.21*
# of studies in bNAber:1Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201170*52*70*28*67*67*40*60*56*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.19*0.4*0.09*0.19*0.26*0.24*0.04*6.25*0.21*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-8
PutativeJgeneJ6*02
CDR3 length aa32
CDR3sequence aaGSKHRLRDYVLYDDYGLINYQEWNDYLEFLDV
Somatic mutations aa31
Somatic mutations na51
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos0 or +1 in CDR3d
Light Chain
PutativeVgeneIGKV2-28*01 or IGKV2D-28*01
PutativeJgeneIGKJ1*01
CDR3 length aa9
CDR3sequence aaMQGLNRPWT
Somatic mutations na23
Somatic mutations aa46
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201924 Light Chain DNA: JN201924
Heavy Chain AA: JN201907 Heavy Chain DNA: JN201907

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database