Details:

PGT143

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT143 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 84Best neutralization breadth IC50, %:55*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.31*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201167*52*70*28*67*67*40*50*55*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.32*0.39*0.17*0.28*0.45*0.27*0.07*1.11*0.31*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-8*01
PutativeJgeneIGHJ6*02
CDR3 length aa32
CDR3sequence aaGSKHRLRDYVLYDDYGLINYQEWNDYLEFLDV
Somatic mutations aa29
Somatic mutations na51
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos0 or +1 in CDR3d
Light Chain
PutativeVgeneIGKV2-28*01 or IGKV2D-28*01
PutativeJgeneIGKJ1*01
CDR3 length aa9
CDR3sequence aaMQGLNRPWT
Somatic mutations na24
Somatic mutations aa46
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201925 Light Chain DNA: JN201925
Heavy Chain AA: JN201908 Heavy Chain DNA: JN201908

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database