Details:

PGT144

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT144 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 84Best neutralization breadth IC50, %:37*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):2.06*
# of studies in bNAber:1Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201148*39*52*16*53*33*30*20*37*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20112.79*3.56*0.92*5.15*0.51*3.84*0.1*26.17*2.06*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-8*01
PutativeJgeneIGHJ6*02
CDR3 length aa32
CDR3sequence aaGSKHRLRDYVLYDDYGLINQQEWNDYLEFLDV
Somatic mutations aa33
Somatic mutations na59
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos0 or +1 in CDR3d
Light Chain
PutativeVgeneIGKV2-28*01 or IGKV2D-28*01
PutativeJgeneIGKJ1*01
CDR3 length aa9
CDR3sequence aaMQGLNRPWT
Somatic mutations na25
Somatic mutations aa44
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN201926 Light Chain DNA: JN201926
Heavy Chain AA: JN201909 Heavy Chain DNA: JN201909

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database