Details:

PGT145

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT145 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3U1S

3D Structure Viewer: 3U1S
Donor:Donor 84Best neutralization breadth IC50, %:78*
Binding Site:V1/V2Neutralization breadth IC80, %:NA
Primary Reference:21849977Best neutralization potency (in μg/ml):0.12*
# of studies in bNAber:2Polyreactivity:Not Reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201181*77*70*72*100*80*90*70*78*
Sok201483*60*72*100*NA83*71*75*75*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.44*0.09*0.14*1.16*0.82*0.11*0.97*0.16*0.29*
Sok20140.99*0.03*0.15*0.2*NA0.02*0.12*4.19*0.12*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-8
PutativeJgeneJ6*02
CDR3 length aa31
CDR3sequence aaGSKHRLRDYFLYNEYGPNYEEWGDYLATLDV
Somatic mutations aa39
Somatic mutations na72
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos-1 or 0 in CDR3d
Light Chain
PutativeVgeneIGKV2-28*01 or IGKV2D-28*01
PutativeJgeneIGKJ1*01
CDR3 length aa9
CDR3sequence aaMQGLHSPWT
Somatic mutations na26
Somatic mutations aa52
Mutation frequency na0.1
Mutation frequency aa0.2
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDB
3U1S
GenBankLight Chain AA: JN201927 Light Chain DNA: JN201927
Heavy Chain AA: JN201910 Heavy Chain DNA: JN201910

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database