Details:

PGT152

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:PGT152 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 4NUJ

3D Structure Viewer: 4NUJ
Donor:Donor 31Best neutralization breadth IC50, %:64*
Binding Site:gp41 and gp120 interface residues and glycansNeutralization breadth IC80, %:NA
Primary Reference:24768347Best neutralization potency (in μg/ml):0.01*
# of studies in bNAber:1Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Falkowska201475*88*69*75*NA57*14*63*64*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Falkowska20140.01*0.02*0.01*0.08*NA0.01*1.94*0.01*0.01*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV3-30*04
PutativeJgeneIGHJ6*02
CDR3 length aa
CDR3sequence aa
Somatic mutations aa
Somatic mutations na
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV2D-29*02
PutativeJgeneIGKJ4*01
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
External Resources:
EMDataBankNA
PDB
4NUJ
GenBank
NA

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database