Details:

VRC-CH31

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC-CH31 - XML ExportAlternate Names:CH31Representative Structure: 4LSP

3D Structure Viewer: 4LSP 4LSQ 4LSR
Donor:Donor 0219Best neutralization breadth IC50, %:92*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21835983Best neutralization potency (in μg/ml):0*
# of studies in bNAber:2Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev201395*84*75*100*NANA100*100*85*
Wu201196*89*96*78*NA100*94*94*92*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev20130.04*0.14*0.19*22.98*NANA0.18*0.12*0.14*
Wu20110.02*0*0*0.17*NA0*0.03*0*0*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ4*02
CDR3 length aa15
CDR3sequence aaARAQKRGRSEWAYAH
Somatic mutations aa37
Somatic mutations na72 (74)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1-33*01
PutativeJgeneIGKJ2*01
CDR3 length aa5
CDR3sequence aaCQQYETF
Somatic mutations na20 (22)
Somatic mutations aa42 (44)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
4LSP4LSQ4LSR
GenBankLight Chain AA: JN159438 Light Chain DNA: JN159438
Heavy Chain AA: JN159435 Heavy Chain DNA: JN159435

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database