Details:

VRC-CH33

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC-CH33 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 0219Best neutralization breadth IC50, %:*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21835983Best neutralization potency (in μg/ml):*
# of studies in bNAber:0Polyreactivity:
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
There was no neutralization data found!
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ4*02
CDR3 length aa15
CDR3sequence aaARAQKRARSEWAYAH
Somatic mutations aa36
Somatic mutations na73 (75)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV1-33*01
PutativeJgeneIGKJ2*01
CDR3 length aa5
CDR3sequence aaCQQYETF
Somatic mutations na22 (24)
Somatic mutations aa47 (49)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN159470 Light Chain DNA: JN159470
Heavy Chain AA: JN159472 Heavy Chain DNA: JN159472

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database