Details:

VRC-PG04

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC-PG04 - XML ExportAlternate Names:PGV04Representative Structure: 3SE9

3D Structure Viewer: 3SE9 4I3R 4I3S 3J5M
Donor:Donor 74Best neutralization breadth IC50, %:82*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21835983Best neutralization potency (in μg/ml):0.14*
# of studies in bNAber:2Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev201395*84*71*50*NANA100*100*82*
Wu201193*82*70*56*NANA75*75*76*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev20130.06*0.19*0.15*0.13*NANA0.15*0.8*0.14*
Wu20110.06*0.23*0.31*0.38*NANA0.27*0.26*0.17*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ2*01
CDR3 length aa16
CDR3sequence aaARQKFYTGGQGWYFDL
Somatic mutations aa42
Somatic mutations na84 (85)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20*01
PutativeJgeneIGKJ5*01
CDR3 length aa5
CDR3sequence aaCQQLEFF
Somatic mutations na26 (29)
Somatic mutations aa54 (58)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDB
3SE94I3R4I3S3J5M
GenBankLight Chain AA: JN159466 Light Chain DNA: JN159466
Heavy Chain AA: JN159464 Heavy Chain DNA: JN159464

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database