Details:

VRC-PG04b

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC-PG04b - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 74Best neutralization breadth IC50, %:71*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:21835983Best neutralization potency (in μg/ml):0.2*
# of studies in bNAber:1Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Wu201193*76*63*56*NANA75*63*71*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Wu20110.07*0.16*0.33*1.1*NANA0.24*0.42*0.2*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ2*01
CDR3 length aa16
CDR3sequence aaARQKFERGGQGWYFDL
Somatic mutations aa42
Somatic mutations na82 (83)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20*01
PutativeJgeneIGKJ5*01
CDR3 length aa5
CDR3sequence aaCQQVEFF
Somatic mutations na26 (29)
Somatic mutations aa52 (56)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankNA
PDBNA
GenBankLight Chain AA: JN159467 Light Chain DNA: JN159467
Heavy Chain AA: JN159465 Heavy Chain DNA: JN159465

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database