Details:

VRC01

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC01 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3NGB

3D Structure Viewer: 3NGB 4LSS 4LST
Donor:Donor 45Best neutralization breadth IC50, %:93*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:20616233Best neutralization potency (in μg/ml):0.09*
# of studies in bNAber:9Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker201193*100*89*84*100*93*100*90*93*
Chuang2013100*92*85*89*NANA94*89*89*
Huang2012100*92*85*89*NANA94*81*88*
Scheid2011100*100*88*100*NA86*100*75*92*
Liao2013100*92*85*NANANANANA91*
Georgiev2013100*94*82*50*NANA100*100*90*
Wu2010100*95*87*88*NA90*94*86*91*
Wu2011100*92*85*89*NANA94*81*89*
Huang2014100*92*85*89*NANA94*81*88*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Walker20110.25*0.24*0.49*0.44*0.39*0.1*0.57*0.12*0.31*
Chuang20130.12*0.35*0.31*0.47*NANA0.3*0.2*0.23*
Huang20120.09*0.36*0.26*0.5*NANA0.33*0.16*0.24*
Scheid20110.09*0.22*0.05*0.08*NA0.17*0*0.56*0.09*
Liao20130.09*0.37*0.26*NANANANANA0.23*
Georgiev20130.12*0.24*0.27*0.11*NANA0.33*0.07*0.2*
Wu20100.11*0.35*0.34*0.57*NA0.21*0.39*0.14*0.33*
Wu20110.11*0.28*0.32*0.46*NANA0.37*0.23*0.25*
Huang20140.09*0.36*0.26*0.5*NANA0.33*0.16*0.24*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ1*01 or IGHJ2*01
CDR3 length aa14
CDR3sequence aaTRGKNCDYNWDFEH
Somatic mutations aa41
Somatic mutations na93 (95)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-11*01
PutativeJgeneIGKJ2*01
CDR3 length aa5
CDR3sequence aaCQQYEFF
Somatic mutations na24
Somatic mutations aa44
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankEMD-5457
EMDataBankEMD-5461
PDB
3NGB4LSS4LST
GenBankLight Chain AA: GU980703 Light Chain DNA: GU980703
Heavy Chain AA: GU980702 Heavy Chain DNA: GU980702

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database