Details:

VRC02

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC02 - XML ExportAlternate Names:No alternate names knownNo structure data available!
Donor:Donor 45Best neutralization breadth IC50, %:91*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:20616233Best neutralization potency (in μg/ml):0.13*
# of studies in bNAber:2Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev2013100*94*82*50*NANA100*100*90*
Wu2010100*92*87*88*NA90*94*86*91*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Georgiev20130.09*0.14*0.21*0.1*NANA0.29*0.06*0.13*
Wu20100.1*0.43*0.33*0.68*NA0.29*0.38*0.14*0.31*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ1*01 or IGHJ2*01
CDR3 length aa14
CDR3sequence aaTRGKNCDYNWDFEH
Somatic mutations aa39
Somatic mutations na94 (96)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-11*01
PutativeJgeneIGKJ2*01
CDR3 length aa5
CDR3sequence aaCQQYEFF
Somatic mutations na26
Somatic mutations aa48
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankEMD-5459
EMDataBankEMD-5460
PDBNA
GenBankLight Chain AA: GU980705 Light Chain DNA: GU980705
Heavy Chain AA: GU980704 Heavy Chain DNA: GU980704

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database