Details:

VRC03

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:VRC03 - XML ExportAlternate Names:No alternate names knownRepresentative Structure: 3SE8

3D Structure Viewer: 3SE8
Donor:Donor 45Best neutralization breadth IC50, %:62*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:20616233Best neutralization potency (in μg/ml):0.04*
# of studies in bNAber:4Polyreactivity:Negative in in vitro assay reported
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201357*79*48*22*NANA25*22*50*
Georgiev201350*77*36*NANANANANA52*
Wu201064*73*58*25*NA60*31*29*57*
Wu201175*82*72*33*NANA31*25*62*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20130.34*0.15*0.36*19.8*NANA0.71*0.28*0.22*
Georgiev20130.43*0.12*2.02*NANANANANA0.28*
Wu20100.4*0.19*1*16.33*NA1.19*2.4*0.11*0.3*
Wu20110.03*0.04*0.03*0.06*NANA0.99*0.07*0.04*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-02*02
PutativeJgeneIGHJ1*01
CDR3 length aa16
CDR3sequence aaVRRGSCDYCGDFPWQY
Somatic mutations aa39 (40)
Somatic mutations na85 (91)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20*01
PutativeJgeneIGKJ2*01
CDR3 length aa5
CDR3sequence aaCQQFEFF
Somatic mutations na26 (28)
Somatic mutations aa57 (62)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankEMD-5458
PDB
3SE8
GenBankLight Chain AA: GU980707 Light Chain DNA: GU980707
Heavy Chain AA: GU980706 Heavy Chain DNA: GU980706

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database