Details:

b12

Broad neutralization coverage of HIV by multiple highly potent antibodies
bNAb:b12 - XML ExportAlternate Names:IgG1b12Representative Structure: 2NY7

3D Structure Viewer: 2NY7 3RU8
Donor:unknownBest neutralization breadth IC50, %:54*
Binding Site:CD4bsNeutralization breadth IC80, %:NA
Primary Reference:20616233Best neutralization potency (in μg/ml):0.79*
# of studies in bNAber:5Polyreactivity:No
Competition of bNAbs with sCD4 and bNAbs in ELISA:
sCD4b12a2G12F425X5PG9PGT121PGT125PGT130PGT135
NANANANANANANANANANA
Percent viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang201350*69*33*67*NANA13*11*44*
Walker200930*58*33*48*NA13*50*30*36*
Liao201356*69*35*NANANANANA51*
Georgiev201350*74*39*50*NANANANA54*
Wu201045*62*47*63*NANA6*29*41*
Median IC50 (μg/ml) against viruses neutralized with an IC50 < 50 μg/ml:
StudyABCDFGAEAGAll clades
Chuang20134.26*0.78*1.41*0.73*NANA30.3*2.51*0.91*
Walker20096.98*0.81*5.46*1.47*NA3.08*17.1*10.4*2.74*
Liao20134.26*0.78*1.44*NANANANANA0.91*
Georgiev20131.5*0.25*0.9*0.15*NANANANA0.79*
Wu20101.66*0.97*6.26*1.1*NANA41.2*3.81*1.5*
Sequence Information:
Heavy Chain
PutativeVgeneIGHV1-03*01
PutativeJgeneIGHJ6*03
CDR3 length aa20
CDR3sequence aaARVGEWGWDDSPYDNYYMDV
Somatic mutations aa21
Somatic mutations na42 (43)
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Light Chain
PutativeVgeneIGKV3-20*01
PutativeJgeneIGKJ2*01
CDR3 length aa
CDR3sequence aa
Somatic mutations na
Somatic mutations aa
Mutation frequency na
Mutation frequency aa
InsertionDeletions aa pos
Ab sequence characteristics were generated using IGMT/HighV-QUEST and IgAT programs.
External Resources:
EMDataBankEMD-5018
EMDataBankEMD-5021
PDB
2NY73RU8
GenBankLight Chain AA: AFQ31505
Heavy Chain AA: AFQ31504

Asterisk (*) indicates value are computed by bNAber from IC50 data on the fly

Key/Legend for Neutralization Breadth
Color Description
Neutralization > 90%
90% >= Neutralization > 60%
60% >= Neutralization > 30%
Neutralization < 30%
Neutralization data is not available in bNAber database
Key/Legend for Neutralization Potency
Color Description
Potency < 0.2 μg/ml
0.2 μg/ml <=Potency < 2 μg/ml
2 μg/ml <= Potency < 20 μg/ml
Potency data is not available in bNAber database