4J6R: CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC23 IN COMPLEX WITH HIV-1 GP120


G: ENVELOPE GLYCOPROTEIN GP160
H: HEAVY CHAIN OF ANTIBODY VRC23
L: LIGHT CHAIN OF ANTIBODY VRC23





Epitopes

Chain G: N279 S365 G366 G367 D368 I371 A430 D457 G458 G459 K460 D461 N462 N463 G473


Paratopes

Chain H: E53 R54 G55 A56 V57 S58 Y59 A60 P61

Chain L: E1 I2 V3 Y91 E96 T97


Contact Points


Contacting ChainContacting ResidueContacting PositionContacted ChainContacted ResidueContacted Position
GASN279LTYR91
GSER365HVAL57
GSER365HSER58
GGLY366HALA56
GGLY366HVAL57
GGLY366HGLY55
GGLY367HARG54
GGLY367HVAL57
GGLY367HGLY55
GGLY367HALA56
GASP368HGLY55
GASP368HALA56
GASP368HARG54
GILE371HARG54
GALA430HGLU53
GASP457HTYR59
GASP457HSER58
GASP457HALA60
GGLY458LGLU96
GGLY458HALA60
GGLY458HPRO61
GGLY459LGLU96
GGLY459HPRO61
GGLY459HALA60
GLYS460LGLU96
GLYS460LTHR97
GLYS460LVAL3
GLYS460LGLU1
GLYS460LILE2
GASP461LILE2
GASP461LGLU1
GASN462LGLU1
GASN463LGLU1
GGLY473HARG54
HGLU53GALA430
HARG54GGLY367
HARG54GASP368
HARG54GILE371
HARG54GGLY473
HGLY55GGLY367
HGLY55GGLY366
HGLY55GASP368
HALA56GGLY366
HALA56GGLY367
HALA56GASP368
HVAL57GGLY367
HVAL57GSER365
HVAL57GGLY366
HSER58GSER365
HSER58GASP457
HTYR59GASP457
HALA60GGLY459
HALA60GASP457
HALA60GGLY458
HPRO61GGLY459
HPRO61GGLY458
LGLU1GASN462
LGLU1GASN463
LGLU1GASP461
LGLU1GLYS460
LILE2GASP461
LILE2GLYS460
LVAL3GLYS460
LTYR91GASN279
LGLU96GGLY458
LGLU96GGLY459
LGLU96GLYS460
LTHR97GLYS460