4LSU: CRYSTAL STRUCTURE OF BROADLY AND POTENTLY NEUTRALIZING ANTIBODY VRC- PG20 IN COMPLEX WITH HIV-1 CLADE A/E 93TH057 GP120


G: HIV-1 CLADE A/E STRAIN 93TH057 GP120
H: HEAVY CHAIN OF ANTIBODY VRC-PG20
L: LIGHT CHAIN OF ANTIBODY VRC-PG20





Epitopes

Chain G: G124 N279 A281 S365 G366 G367 D368 E370 I371 D457 G458 G459 A460 N461


Paratopes

Chain H: E100B W47 W54 G55 V57 N58 Y59 A60 R61 T62 Y74

Chain L: F91 E96 F97


Contact Points


Contacting ChainContacting ResidueContacting PositionContacted ChainContacted ResidueContacted Position
GGLY124HTYR74
GASN279LPHE91
GALA281HGLU100B
GSER365HASN58
GSER365HVAL57
GGLY366HVAL57
GGLY366HGLY55
GGLY367HGLY55
GGLY367HVAL57
GGLY367HTRP54
GASP368HGLY55
GASP368HTRP54
GGLU370HTRP54
GILE371HTRP54
GASP457HALA60
GASP457HARG61
GASP457HASN58
GASP457HTYR59
GGLY458HASN58
GGLY458HTYR59
GGLY458HARG61
GGLY458HALA60
GGLY458LGLU96
GGLY459HARG61
GGLY459LPHE97
GGLY459LGLU96
GGLY459HALA60
GGLY459HTRP47
GALA460HALA60
GALA460HARG61
GALA460HTHR62
GASN461HARG61
HGLU100^BGALA281
HTRP47GGLY459
HTRP54GGLU370
HTRP54GASP368
HTRP54GILE371
HTRP54GGLY367
HGLY55GASP368
HGLY55GGLY367
HGLY55GGLY366
HVAL57GGLY367
HVAL57GGLY366
HVAL57GSER365
HASN58GASP457
HASN58GGLY458
HASN58GSER365
HTYR59GASP457
HTYR59GGLY458
HALA60GGLY459
HALA60GALA460
HALA60GGLY458
HALA60GASP457
HARG61GASP457
HARG61GGLY458
HARG61GALA460
HARG61GASN461
HARG61GGLY459
HTHR62GALA460
HTYR74GGLY124
LPHE91GASN279
LGLU96GGLY458
LGLU96GGLY459
LPHE97GGLY459